BackgroundIdentifying new biomarkers of major depressive disorder (MDD) would be of great significance for its early diagnosis and treatment.Herein, we constructed a diagnostic model of MDD using machine learning methods.MethodsThe GSE98793 and GSE19738 datasets were obtained from the Gene Expression Omnibus database, and the limma R package was us
Cytosine methylation/demethylation plays pivotal roles in regulating gene expression at a genome-wide level.However, limited reports are available to reveal correlating changes of cytosine methylation and proteomic expression in Brassica napus so far.Therefore, in the present study, global cytosine methylation and proteome were analysed in B.napus
Abstract Cultivation practice using organic amendments is plausible to ensure global food security.However, plant abiotic stress due to the presence of metals and organic microcontaminants (OMCs) in fertilization products cannot be overlooked.In this study, we monitored lettuce metabolism and phenotypic response following the application of either
Coordinated regulation of gene activity by transcriptional and translational mechanisms poise stem cells for a timely cell-state transition during differentiation.Although important for all stemness-to-differentiation transitions, mechanistic understanding of the fine-tuning of gene transcription is lacking due to the compensatory effect of transla
This research embarks on an archaeological investigation of the sixty-eight fresh documented unexcavated Neolithic and Megalithic sites scattered throughout Kashmir Valley, India.Focused on three key aspects - landscape, settlement patterns, and material culture, the study aims to unveil the hidden historical treasures of this region.By employing a